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Antiphospholipid syndrome is a disorder of recurrent vascular thrombosis, pregnancy loss and thrombocytopenia associated with persistently elevated levels of antiphospholipid antibodies. It was first described in a group of patients with systemic lupus erythematosus but has since been associated with a wide range of conditions, including other autoimmune disorders and malignancy. It can also occur in isolation, the so-called primary antiphospholipid syndrome. We describe an elderly woman with the antiphospholipid syndrome thought to be associated with a cholangiocarcinoma.

Original publication




Journal article


Postgrad Med J

Publication Date





45 - 46


Aged, Antiphospholipid Syndrome, Bile Duct Neoplasms, Bile Ducts, Intrahepatic, Cholangiocarcinoma, Fatal Outcome, Female, Humans, Recurrence, Venous Thrombosis