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We have sequenced and fully annotated a 65,871-bp region of mouse Chromosome 17 including the Hba-ps4 alpha-globin pseudogene. Comparative sequence analysis with the functional alpha-globin loci at human Chromosome 16p13.3 and mouse Chromosome 11 shows that this segment of mouse Chromosome 17 contains a group of three alpha-like pseudogenes (Hba-psm-Hba-ps4-Hba-q3), similar to the duplicated sets found at the functional mouse cluster on Chromosome 11. In addition, exons 7 to 12 of the mLuc7L gene are present just downstream from the pseudogene cluster, indicating that this clone contains the region in which human 16p13.3 switches in synteny between mouse Chromosomes 11 and 17. Comparison of the sequences around the alpha-like clusters on the two mouse chromosomes reveals the presence of conserved tandem repeats. We propose that these repetitive elements have played a role in the fragmentation of the mouse alpha cluster during evolution.

Original publication

DOI

10.1101/gr.2143604

Type

Journal article

Journal

Genome Res

Publication Date

04/2004

Volume

14

Pages

623 - 630

Keywords

Animals, Chromosome Mapping, Chromosomes, Conserved Sequence, Globins, Hemoglobin A, Humans, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Multigene Family, Pseudogenes, RNA-Binding Proteins, Rats, Species Specificity, Synteny