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BACKGROUND: Young females exhibit lower cardiovascular event rates that young men, a pattern which is lost, or even reversed with advancing age. As aortic stiffness is a powerful risk factor for cardiovascular events, a gender difference with advancing age could provide a plausible explanation for this pattern. METHODS: 777 subjects (♀n = 408, ♂n = 369) across a wide range of age (21-85 years) underwent cardiovascular magnetic resonance to assess aortic pulse wave velocity (PWV) and, in addition, aortic distensibility at three levels; 1) ascending aorta (Ao) and 2) proximal descending aorta (PDA) at the level of the pulmonary artery and 3) the abdominal aorta (DDA). RESULTS: There was a strong negative correlation between increasing age and regional aortic distensibility (Ao♀R-0.84, ♂R-0.80, PDA♀R-0.82, ♂R-0.77, DDA♀R-0.80, ♂R-0.71 all p 

Original publication




Journal article


J Cardiovasc Magn Reson

Publication Date





Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Aging, Aorta, Aortic Diseases, Cross-Sectional Studies, Elasticity, Female, Health Status Disparities, Humans, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Predictive Value of Tests, Pulse Wave Analysis, Reference Values, Risk Factors, Sex Distribution, Sex Factors, Vascular Stiffness, Young Adult