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Innate lymphoid cells are an emerging family of effector cells that contribute to lymphoid organogenesis, metabolism, tissue remodelling and protection against infections. They maintain homeostatic immunity at barrier surfaces such as lung, skin and gut (Nature 464:1367-1371, 2010, Nat Rev Immunol 13: 145-149, 2013). Several human and mouse studies suggest a role for innate lymphoid cells in inflammatory skin conditions including atopic eczema and psoriasis. Here we review the innate lymphoid cell family and discuss their function in the skin and during inflammation.

Original publication

DOI

10.1186/1471-5945-14-18

Type

Journal article

Journal

BMC Dermatol

Publication Date

26/11/2014

Volume

14

Keywords

Animals, Cytokines, Dermatitis, Atopic, Homeostasis, Humans, Immunity, Innate, Lymphocytes, Mice, Psoriasis, Skin