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Increased levels of allergen-specific T-cells have been documented in the peripheral blood of patients with atopic dermatitis (AD) compared with nonatopic controls. However, little is known about how these relate to disease severity. This study sought to examine if frequencies of circulating allergen-specific T cells correlate with changes in clinical disease severity in a cohort of seven adults with AD who were positive for human leucocyte antigen DRB1*1501. We found that frequencies of allergen-specific CD4+ T cells across the study group were not significantly (P > 0.05) associated with clinical disease severity; however, longitudinal changes within an individual did correlate significantly (P < 0.01) with changes in disease severity. These findings support a role for allergen-specific T-cells in disease pathogenesis.

Original publication

DOI

10.1111/j.1365-2230.2010.03791.x

Type

Journal article

Journal

Clin Exp Dermatol

Publication Date

10/2010

Volume

35

Pages

786 - 788

Keywords

Adult, Allergens, Antigens, Dermatophagoides, Arthropod Proteins, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Cells, Cultured, Cysteine Endopeptidases, Dermatitis, Atopic, Follow-Up Studies, Genetic Predisposition to Disease, HLA-DR Antigens, HLA-DRB1 Chains, Humans, Immunity, Cellular, Severity of Illness Index