Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Conflicting results have been published on the prognostic significance of t(14;18) in follicular lymphoma: Yunis et al. (1989) reported that its presence indicated poor response to therapy and short survival, whereas Levine et al. (1988) showed no difference in prognosis between cases with and without the translocation. However these results were based on small series of cases and on follow-up periods (no longer than 7 years) which are relatively short for a disease with such a slow clinical evolution. Here we report an investigation of 70 cases of follicular lymphoma with long term follow-up data (up to 17 years). This series has been studied for the presence of the 14;18 translocation and for the expression of bcl-2 protein. Our results show that there are no grounds for considering either the 14;18 translocation or the expression of the bcl-2 protein to be useful prognostic markers in clinical practice.

Type

Journal article

Journal

Br J Cancer

Publication Date

01/1992

Volume

65

Pages

87 - 89

Keywords

Blotting, Southern, Chromosomes, Human, Pair 14, Chromosomes, Human, Pair 18, Female, Follow-Up Studies, GTP-Binding Proteins, Gene Expression, Gene Rearrangement, Humans, Immunohistochemistry, Lymphoma, Follicular, Male, Middle Aged, Polymerase Chain Reaction, Prognosis, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Translocation, Genetic