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Rearrangements which are most readily explained by homologous crossover between misaligned segments of DNA in the region of the human embryonic zeta (zeta) globin genes have been identified in individuals of three different racial origins. These recombination events have resulted in a surprisingly high prevalence of chromosomes with single (0.4%) and triplicated (1.3%) zeta genes with apparently no significant effect on the phenotype.

Type

Journal article

Journal

Nucleic Acids Res

Publication Date

1982

Volume

10

Pages

5853 - 5868

Keywords

Chromosomes, Human, 16-18 Crossing Over (Genetics) DNA Restriction Enzymes Embryo Female *Genes, Structural Human Nucleic Acid Hybridization Pregnancy Racial Stocks Support, Non-U.S. Gov't Thalassemia/genetics