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A new polymorphic BgI II restriction endonuclease site in the alpha-globin gene complex has been found in Cypriot, Sardinian, and Greek populations. In all cases, this polymorphism is linked to a particular hypervariable region between the zeta 2 and zeta 1 genes. This suggests that these hypervariable regions are stable and will be useful for genetic analysis.

Type

Journal article

Journal

Am J Hum Genet

Publication Date

1983

Volume

35

Pages

1086 - 1089

Keywords

*Chromosome Mapping *Chromosomes, Human, 16-18 Cyprus DNA/analysis/*genetics DNA Restriction Enzymes/diagnostic use *Genes, Structural Globins/*genetics Greece Homozygote Human Italy *Polymorphism (Genetics)