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We have characterised an unusual, highly polymorphic region of DNA located 8-kb downstream of the human alpha-globin gene complex. This hypervariable region (alpha-globin 3' HVR) is composed of an array of 17-bp tandem repeats, the number of which differs considerably (70-450) from one allele to another. The sequence of the 17-bp repeats is highly conserved within and between alleles. Furthermore, this sequence identifies a core oligonucleotide [5'-GNGGGG(N)ACAG-3'] that is common to three previously characterised hypervariable regions. At reduced stringency, a probe to the 3' HVR detects a new family of multiallelic loci that will be of value in the study of human genetics.

Type

Journal article

Journal

Embo J

Publication Date

1986

Volume

5

Pages

1857 - 1863

Keywords

Alleles Base Sequence Cloning, Molecular DNA Restriction Enzymes Evolution *Genes, Structural Globins/*genetics Human Nucleic Acid Hybridization Repetitive Sequences, Nucleic Acid Support, Non-U.S. Gov't *Variation (Genetics)