Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We have studied the interaction of the alpha alpha alpha/alpha alpha gene arrangement with various beta globin genotypes (AA, AS, AC, SS and SC). Whereas this interaction has no detectable clinical or haematological effects in subjects with AA, SS or SC genotypes it is associated with a significantly increased level of Hb S or Hb C in heterozygotes for these variants. These findings indicate that the additional alpha globin gene in the alpha alpha alpha gene arrangement is functional.

Type

Journal article

Journal

Br J Haematol

Publication Date

1984

Volume

57

Pages

671 - 678

Keywords

Adolescent Adult Anemia, Sickle Cell/blood/genetics Child Chromosome Mapping DNA Restriction Enzymes Female Genotype Globins/*genetics Hemoglobin C/analysis Hemoglobin SC Disease/blood/genetics *Hemoglobin, Sickle/analysis Heterozygote Homozygote Human Male