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Homozygous alpha+ thalassaemia (alpha-/alpha-) ameliorates some of the clinical manifestations of homozygous sickle cell (SS) disease but its effect on retinal complications remains unknown. This has been assessed by visual examination and fluorescein angiography in 39 subjects with SS disease and homozygous alpha+ thalassaemia and in 39 age/sex matched controls with SS disease but with a normal alpha globin genotype (alpha alpha/alpha alpha). The results indicate that homozygous alpha+ thalassaemia reduces the extent of peripheral retinal vessel closure but has no apparent effect on the frequency of proliferative sickle retinopathy.

Type

Journal article

Journal

Br J Ophthalmol

Publication Date

1993

Volume

77

Pages

89 - 90

Keywords

Adolescent Adult Age Factors Aged Anemia, Sickle Cell/*complications/genetics Female Fluorescein Angiography Homozygote Human Male Middle Age Retinal Diseases/*etiology Sex Factors alpha-Thalassemia/*complications