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The global epidemic of obesity and the metabolic syndrome has focused the need for novel treatments. Here we describe the putative pathogenic role of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an enzyme that generates active glucocorticoid, cortisol, within liver and adipose tissue. Furthermore, we review the published literature on the development of selective 11β-HSD1 inhibitors as a therapeutic strategy in light of their emerging role as insulin sensitisers. © 2005 Elsevier Ltd. All rights reserved.

Original publication

DOI

10.1016/j.ddstr.2005.05.006

Type

Journal article

Journal

Drug Discovery Today: Therapeutic Strategies

Publication Date

26/07/2005

Volume

2

Pages

93 - 96