P644Mechanisms of myocardial nitroso redox imbalance following elective cardiac surgery on cardiopulmonary bypass.
Jayaram R., Goodfellow N., Nahar K., Zhang M., Reilly S., Crabtree M., De Silva R., Sayeed R., Casadei B.
The mechanisms responsible for myocardial stunning after cardiac surgery are only partially understood, although ischemia - reperfusion (IR) injury associated with cardio pulmonary bypass (CPB) may play an important role. Reactive oxygen species and nitric oxide have been implicated in both myocardial injury and cardio protection suggesting that identification of their sources may refine therapeutic strategies. Here we investigated the effect of cardioplegia, CPB and reperfusion on myocardial nitroso--redox balance in patients after cardiac surgery.