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Patients with cardiovascular disease and impaired glucose tolerance are at increased risk of cardiovascular events and type 2 diabetes mellitus (T2DM). Lifestyle modification or pharmacological intervention can delay progression to T2DM, but there is no clear evidence that they reduce cardiovascular risk in this population. Acarbose, an α-glucosidase inhibitor that lowers postprandial blood glucose, has been shown to reduce T2DM risk by 25%, and possibly cardiovascular risk in impaired glucose tolerance subjects without cardiovascular disease.

Original publication




Journal article


Am Heart J

Publication Date





23 - 9.e2


Acarbose, Blood Glucose, Coronary Disease, Diabetes Mellitus, Type 2, Disease Progression, Double-Blind Method, Follow-Up Studies, Glucose Intolerance, Humans, Hypoglycemic Agents, Prospective Studies, Secondary Prevention, Treatment Outcome