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The purpose of this work was to develop high-resolution cardiac magnetic resonance imaging techniques for the in vivo mouse model for quantification of myocardial function and mass. Eight male mice were investigated on a 7-Tesla MRI scanner. High-quality images in multiple short axis slices (in-plane resolution 117 microm2, slice thickness 1 mm) were acquired with an ECG-gated cine sequence. Left ventricular end-diastolic and end-systolic volumes and mass were calculated from segmented slice volumes. There was precise agreement of left ventricular mass determined ex vivo and by MRI. Intraobserver (5%) and interobserver (5%) variability of in vivo MR measurements were low.


Journal article


Magn Reson Med

Publication Date





43 - 48


Animals, Diastole, Heart Ventricles, Image Enhancement, Magnetic Resonance Imaging, Male, Mice, Mice, Inbred C57BL, Models, Anatomic, Observer Variation, Phantoms, Imaging, Reference Values, Sensitivity and Specificity, Systole, Ventricular Function, Left, Ventricular Function, Right