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Studies published in recent years have highlighted the role of epidermal barrier defects in both atopic skin disease and the development of broader allergic manifestations. While genetic determinants of barrier function are important, it is clear that local acquired effects are also involved in disease pathogenesis. In this review, we aimed to summarize the known influences of cytokines abundantly expressed during atopic skin disease on components of epidermal barrier integrity and function.

Original publication




Journal article


Clin Exp Allergy

Publication Date





586 - 598


Animals, Cell Adhesion Molecules, Cell Differentiation, Cytokines, Epidermis, Humans, Inflammation, Intercellular Junctions, Intermediate Filament Proteins, Keratinocytes, Lipid Metabolism, Peptide Hydrolases, Signal Transduction, Skin, Water