Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We describe a mutant human cell line (LBL 721.174) that has lost a function required for presentation of intracellular viral antigens with class I molecules of the major histocompatibility complex (MHC), but retains the capacity to present defined epitopes as extracellular peptides. The cell also has a defect in the assembly and expression of class I MHC molecules, which we show can be restored by exposure of the cells to a peptide epitope. This phenotype suggests a defect in the association of intracellular antigen with class I molecules similar to that described for the murine mutant RMA-S (ref. 5), but in the present case the genetic defect can be mapped within the MHC locus on human chromosome 6.

Original publication

DOI

10.1038/345449a0

Type

Journal article

Journal

Nature

Publication Date

31/05/1990

Volume

345

Pages

449 - 452

Keywords

Antigen-Presenting Cells, Antigens, Viral, Cell Line, Chromosomes, Human, Pair 6, Histocompatibility Antigens Class I, Humans, Influenza A virus, Major Histocompatibility Complex, Oligopeptides, Precipitin Tests, Viral Matrix Proteins