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Parafibromin is a predominantly nuclear protein with a tumour suppressor role in the development of hereditary and nonhereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour syndrome, which is associated with renal and uterine tumours. Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications. The parafibromin/PAF1 complex regulates genes involved in cell growth and survival, and via these, parafibromin plays a pivotal role in embryonic development and survival of adults.

Original publication




Journal article


J Intern Med

Publication Date





84 - 98


Amino Acid Sequence, Animals, Genetic Predisposition to Disease, Humans, Hyperparathyroidism, Jaw Neoplasms, Molecular Sequence Data, Neoplasm Proteins, Neoplastic Syndromes, Hereditary, Parathyroid Neoplasms, Tumor Suppressor Proteins