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Based on the crystal structures of human alpha-GalCer-CD1d and iNKT-alpha-GalCer-CD1d complexes, nonglycosidic analogues of alpha-GalCer were synthesized. They activate iNKT cells resulting in dendritic cell maturation and the priming of antigen-specific T and B cells. Therefore, they are attractive adjuvants in vaccination strategies for cancer and infectious diseases.

Original publication

DOI

10.1002/cmdc.200800354

Type

Journal article

Journal

ChemMedChem

Publication Date

02/2009

Volume

4

Pages

171 - 175

Keywords

Adjuvants, Immunologic, Animals, Cell Line, Glycosides, Humans, Killer Cells, Natural, Mice, Vaccines