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Over the last few years, several patients with defects in the HLA class I presentation pathway have been described. Analysis of their clinical symptoms and immunological parameters have led to the identification of several unexpected findings which are of importance to understand the role of HLA class I-dependent immune responses in host defense. Here, we will describe and compare clinical manifestations and immunological findings of patients with defects in the peptide transporter proteins (TAP complex), tapasin and CD8 molecules.

Original publication

DOI

10.1016/j.smim.2006.07.006

Type

Journal article

Journal

Semin Immunol

Publication Date

12/2006

Volume

18

Pages

330 - 336

Keywords

Animals, Antigen Presentation, Antigens, CD8, Histocompatibility Antigens Class I, Humans, Killer Cells, Natural, Membrane Transport Proteins, Mice, Mice, Knockout, T-Lymphocytes, Cytotoxic