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One of the grand challenges of human genetics to systematically map by gene-association susceptibility genes for complex diseases is underway. High-throughput genotyping platforms have been developed; a comprehensive map of human genetic variation (HapMap) to guide efficient marker selection is imminent and many researchers have assembled suitable cohorts of patients. Expectations are understandably high and it is timely to review the promise and pitfalls of this strategy.

Original publication

DOI

10.1093/hmg/ddi273

Type

Journal article

Journal

Hum Mol Genet

Publication Date

15/10/2005

Volume

14 Spec No. 2

Pages

R157 - R162

Keywords

Chromosome Mapping, Genetic Linkage, Genetic Predisposition to Disease, Genome, Human, Genotype, Humans, Research Design, Statistics as Topic