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The adhesive phenotypes expressed by Plasmodium-falciparum-infected erythrocytes were previously thought simply to permit sequestration of parasites in the peripheral circulation. Recent work has illuminated how falciparum-infected erythrocytes may modulate the function of monocytes, macrophages and myeloid dendritic cells through the action of haemozoin from digested haemoglobin and through adhesion of infected cells to their surface.

Original publication

DOI

10.1016/s0952-7915(02)00368-0

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

08/2002

Volume

14

Pages

458 - 465

Keywords

Animals, Cell Adhesion, Dendritic Cells, Disease Models, Animal, Erythrocytes, Host-Parasite Interactions, Humans, Immune Tolerance, Macrophages, Malaria, Falciparum, Models, Biological, Monocytes, Plasmodium falciparum