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We have identified an HLA-A2-restricted CD8(+) T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but uniquely is dependent upon the immunoproteasome for its generation.

Type

Journal article

Journal

J Virol

Publication Date

02/2003

Volume

77

Pages

2757 - 2761

Keywords

ATP-Binding Cassette Sub-Family B Member 2, ATP-Binding Cassette Transporters, CD8-Positive T-Lymphocytes, Cysteine Endopeptidases, Epitopes, T-Lymphocyte, HLA-A2 Antigen, Herpesvirus 4, Human, Humans, Leukocytes, Mononuclear, Lymphocyte Activation