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In the process of identification of the multiple endocrine neoplasia type 1 gene, which was recently published, we isolated a novel gene in the 11q13 region. This gene (named ZFPL1, for zinc-finger protein-like 1) is expressed strongly in the exocrine pancreas as a 1.4-kb polyadenylated RNA encoding a putative protein of 310 amino acids. A mouse EST contig predicts an equally sized murine protein with 91% amino acid sequence identity to the human protein. No significant homology with known proteins could be found through database screening. However, zinc-finger-like domains and leucine-zipper-like motifs in the predicted ZFPL1 protein were identified, suggesting the presence of DNA-binding and dimerization domains possibly involved in transcription regulation. This notion is supported by the presence of a putative bipartite nuclear localization signal. This paper presents the full-length cDNA sequence for this gene, its genomic structure and chromosomal orientation, and expression studies by Northern blot hybridization and RNA in situ hybridization.

Original publication

DOI

10.1006/geno.1998.5307

Type

Journal article

Journal

Genomics

Publication Date

01/06/1998

Volume

50

Pages

251 - 259

Keywords

Amino Acid Sequence, Animals, Base Sequence, Blotting, Northern, Blotting, Southern, Chromosome Mapping, Chromosomes, Human, Pair 11, DNA, Complementary, DNA-Binding Proteins, Exons, Gene Expression, Humans, In Situ Hybridization, Introns, Leucine Zippers, Mice, Molecular Sequence Data, Pancreas, RNA, Rats, Sequence Analysis, DNA, Zinc Fingers