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The triacylglycerol content of chylomicrons and VLDL (very-low-density lipoprotein) compete for the same lipolytic pathway in the capillary beds. Although chylomicron triacylglycerols appear to be the favoured substrate for lipoprotein lipase, VLDL particles compete in numbers. Methods to quantify the specific triacylglycerol removal from VLDL and chylomicrons may involve endogenous labelling of the triacylglycerol substrate with stable isotopes in combination with arteriovenous blood sampling in humans. Arteriovenous quantification of remnant lipoproteins suggests that adipose tissue with its high lipoprotein lipase activity is a principal site for generation of remnant lipoproteins. Under circumstances of reduced efficiency in the removal of triacylglycerols from lipoproteins, there is accumulation of remnant lipoproteins, which are potentially atherogenic.

Original publication

DOI

10.1042/BST0350472

Type

Conference paper

Publication Date

06/2007

Volume

35

Pages

472 - 476

Keywords

Adipose Tissue, Capillaries, Chylomicron Remnants, Chylomicrons, Humans, Lipoprotein Lipase, Lipoproteins, VLDL, Muscle, Skeletal, Tissue Distribution, Triglycerides