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National guidelines for platelet transfusion in many countries recommend that the general platelet transfusion trigger for prophylaxis is 10x10(9)/l. This annotation reviews the evidence for this threshold level and discusses other current unresolved issues relevant to platelet transfusion practice such as the optimal dose and the clinical benefit of a strategy for the prophylactic use of platelet transfusions when the platelet count falls below a given threshold.

Original publication

DOI

10.1111/j.1365-2141.2005.05769.x

Type

Journal article

Journal

Br J Haematol

Publication Date

12/2005

Volume

131

Pages

588 - 595

Keywords

Guideline Adherence, Hematologic Neoplasms, Hemorrhage, Humans, Patient Selection, Platelet Transfusion, Randomized Controlled Trials as Topic, Thrombocytopenia