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We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several novel non-clade B CTL epitopes, including some restricted by HLA alleles common in Africans. Although cross-clade CTL recognition of these epitopes does occur, recognition can also be highly clade specific.

Type

Journal article

Journal

J Virol

Publication Date

02/1999

Volume

73

Pages

1708 - 1714

Keywords

Africa, Eastern, Amino Acid Sequence, Cells, Cultured, Epitopes, T-Lymphocyte, Female, HIV Infections, HIV-1, Humans, Male, Molecular Sequence Data, T-Lymphocytes, Cytotoxic