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Strong expression of Forkhead box-P1 (FOXP1), a winged-helix transcription factor, has been identified as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers.

Original publication

DOI

10.1002/gcc.20278

Type

Journal article

Journal

Genes Chromosomes Cancer

Publication Date

02/2006

Volume

45

Pages

164 - 168

Keywords

Base Sequence, Chromosomes, Human, Pair 14, Chromosomes, Human, Pair 3, DNA Primers, Forkhead Transcription Factors, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Repressor Proteins, Translocation, Genetic