Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Regulatory T cells (Tregs) can potentially migrate to the B cell areas of secondary lymphoid tissues and suppress T cell-dependent B cell Ig response. T cell-dependent Ig response requires B cell stimulation by Th cells. It has been unknown whether Tregs can directly suppress B cells or whether they must suppress Th cells to suppress B cell response. We report here that Foxp3+ Tregs are found in T-B area borders and within germinal centers of human lymphoid tissues and can directly suppress B cell Ig response. Although Tregs can effectively suppress T cells, they can also directly suppress B cell response without the need to first suppress Th cells. The direct suppression of B cell Ig production by Tregs is accompanied by inhibition of Ig class switch recombination.

Type

Journal article

Journal

J Immunol

Publication Date

01/10/2005

Volume

175

Pages

4180 - 4183

Keywords

B-Lymphocytes, Cells, Cultured, Forkhead Transcription Factors, Humans, Immunoglobulin Class Switching, Palatine Tonsil, Receptors, Cell Surface, Receptors, Interleukin-2, T-Lymphocytes, Regulatory