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Capecitabine (Xeloda) and irinotecan (CPT-11, Camptosar) both have demonstrated single-agent activity in patients with colorectal cancer. In an analysis of pooled results of two phase III studies, capecitabine provided advantages over intravenous fluorouracil (5-FU) plus leucovorin in patients with metastatic colorectal cancer. In another analysis, metastatic colorectal cancer patients who received irinotecan along with 5-FU plus leucovorin had significantly improved overall survival as compared with those who received 5-FU plus leucovorin alone. Capecitabine and irinotecan have distinct mechanisms of action and only partially overlapping toxicities. Combinations of these agents therefore are being explored in patients with colorectal cancer. This report briefly reviews current and ongoing trials evaluating capecitabine/irinotecan combination regimens in treating this disease.

Type

Journal article

Journal

Oncology (Williston Park)

Publication Date

04/2002

Volume

16

Pages

27 - 29

Keywords

Antineoplastic Combined Chemotherapy Protocols, Camptothecin, Capecitabine, Clinical Trials as Topic, Colorectal Neoplasms, Deoxycytidine, Fluorouracil, Humans