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Mutations of the NRAS and TP53 genes and internal tandem duplication (ITD) of the FLT3 gene are among the most frequently observed molecular abnormalities in the myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). We sought to determine the incidence of these abnormalities in patients with MDS and a 5q deletion. NRAS and FLT3 mutations are uncommon in MDS patients with a 5q deletion and TP53 mutation is associated with the more advanced MDS subtypes.

Type

Journal article

Journal

Haematologica

Publication Date

07/2004

Volume

89

Pages

865 - 866

Keywords

Aged, 80 and over, Chromosome Deletion, Chromosomes, Human, Pair 5, Female, Genes, p53, Genes, ras, Humans, Male, Middle Aged, Mutation, Myelodysplastic Syndromes, fms-Like Tyrosine Kinase 3