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HLA-peptide tetrameric complexes allow the direct ex vivo visualisation of antigen-specific CD8+ T cells and natural killer cells by flow cytometry. Quantitation, phenotypic analysis and isolation of tetramer-binding cells has considerably extended our understanding of cytotoxic T lymphocyte and natural killer cell function.

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

08/1998

Volume

10

Pages

393 - 396

Keywords

HLA Antigens, Humans, Peptides