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Cutaneous squamous cell carcinoma is typically characterized by the over-expression of the tumour suppressor protein p53. Considerable evidence suggests that immune competence is important in the control of cutaneous SCC. We discuss the immunobiology of p53 and its relevance to cutaneous SCC, including the potential interaction with human papillomavirus.

Type

Journal article

Journal

Clin Exp Immunol

Publication Date

06/2003

Volume

132

Pages

379 - 384

Keywords

Carcinoma, Squamous Cell, Humans, Immunocompetence, Papillomaviridae, Papillomavirus Infections, Skin Neoplasms, Tumor Suppressor Protein p53, Tumor Virus Infections