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Exocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is crucial to maintenance of plasma glucose levels. They fuse with the plasma membrane in a regulated manner to release their contents and are subsequently recaptured either intact or through conventional clathrin-mediated endocytosis. Here, we discuss these mechanisms in beta-cells at the single-vesicle level.

Original publication

DOI

10.1152/physiol.00047.2006

Type

Journal article

Journal

Physiology (Bethesda)

Publication Date

04/2007

Volume

22

Pages

113 - 121

Keywords

Animals, Cell Membrane, Diabetes Mellitus, Type 2, Electrophysiology, Endocytosis, Exocytosis, Humans, Insulin, Insulin-Secreting Cells, Secretory Vesicles