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Circulating nucleic acids have been shown to have potential as non-invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility by comparing levels of tumour-associated MIRN155 (miR-155), MIRN210 (miR-210) and MIRN21 (miR-21) in serum from diffuse large B-cell lymphoma (DLBCL) patients (n = 60) with healthy controls (n = 43). Levels were higher in patient than control sera (P = 0.009, 0.02 and 0.04 respectively). Moreover, high MIRN21 expression was associated with relapse-free survival (P = 0.05). This is the first description of circulating microRNAs and suggests that microRNAs have potential as non-invasive diagnostic markers for DLBCL and possibly other cancers.

Original publication

DOI

10.1111/j.1365-2141.2008.07077.x

Type

Journal article

Journal

Br J Haematol

Publication Date

05/2008

Volume

141

Pages

672 - 675

Keywords

Adult, Biomarkers, Tumor, Female, Humans, Lymphoma, Large B-Cell, Diffuse, Male, MicroRNAs, Middle Aged, Neoplasm Staging, Prognosis, RNA, Neoplasm, Retrospective Studies, Survival Analysis