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Acquisition weighted (13)C-spectroscopic imaging with three spatial dimensions is demonstrated in the isolated, perfused rat heart. Experiments were performed at 11.75 T with a home-built double resonant (13)C-(1)H probehead. Three-dimensional chemical shift imaging was used to obtain (1)H-decoupled (13)C-spectra in 96-microl voxels in about 58 min. Acquisition weighting significantly reduced signal contamination and improved image quality, with no penalty in sensitivity. As a first application, infarcted hearts were studied during perfusion with [2-(13)C]-sodium acetate. The extent of the incorporation of the (13)C-label into glutamate allows us to distinguish intact and infarcted myocardium. Chemical shift images show a homogeneous glutamate distribution in intact tissue, but a negligible amount in the infarction scar.

Original publication

DOI

10.1006/jmre.1999.1984

Type

Journal article

Journal

J Magn Reson

Publication Date

03/2000

Volume

143

Pages

17 - 23

Keywords

Animals, Carbon Isotopes, Glutamic Acid, Image Processing, Computer-Assisted, In Vitro Techniques, Magnetic Resonance Spectroscopy, Male, Myocardial Infarction, Myocardium, Rats, Rats, Wistar