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Non-genetic mechanisms of transformation are still relatively understudied and poorly understood. In this issue of Cell Stem Cell, Muto et al. provide preclinical evidence that loss of TRAF6 expression promotes transformation through a MYC-dependent mechanism that may be modulated by environmental inflammatory signals.

Original publication

DOI

10.1016/j.stem.2022.01.006

Type

Journal article

Journal

Cell Stem Cell

Publication Date

03/02/2022

Volume

29

Pages

184 - 186