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Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push-pull system.

Original publication

DOI

10.1039/c5cc01224d

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

2015

Volume

51

Pages

6018 - 6021

Keywords

Animals Azo Compounds/*chemistry Calcium/metabolism Cells, Cultured Diazoxide/pharmacology Gene Expression Regulation Guanine Nucleotide Exchange Factors/genetics/metabolism HEK293 Cells Humans Hypoglycemic Agents/pharmacology Insulin/*agonists/metabolism Insulin Secretion Insulin-Secreting Cells/cytology/drug effects/metabolism/*radiation effects Islets of Langerhans/cytology/drug effects/metabolism/*radiation effects Light Mice Photochemical Processes Potassium/metabolism Signal Transduction Sulfonylurea Compounds/*chemistry/pharmacology Sulfonylurea Receptors/genetics/metabolism