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Individual tumors harbor heterogeneous populations of genetically distinct subclones. Two recent papers in Nature by Notta et al. (2011) and Anderson et al. (2011) reveal genetic heterogeneity in functional leukemic stem cells, which has important implications for how both cancer and normal stem cell populations may adapt to selective pressure.

Original publication

DOI

10.1016/j.stem.2011.02.015

Type

Journal article

Journal

Cell Stem Cell

Publication Date

04/03/2011

Volume

8

Pages

242 - 244