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We report the first case of lichen planus pemphigoides (LPP) secondary to ingestion of ramipril, an angiotensin-converting enzyme inhibitor. Clinical, histological and immunofluorescent findings were all consistent with a diagnosis of LPP. Linear basement membrane zone (BMZ) staining with IgG and C3 was only seen at the roof of split-skin preparations and circulating autoantibody to the BMZ was present at a titre of 1/100. Controlled immunoblotting of epidermal extracts detected the bullous pemphigoid antigens of 230 and 180 kDa.

Type

Journal article

Journal

Br J Dermatol

Publication Date

03/1997

Volume

136

Pages

412 - 414

Keywords

Angiotensin-Converting Enzyme Inhibitors, Autoantibodies, Autoantigens, Carrier Proteins, Collagen, Cytoskeletal Proteins, Dystonin, Humans, Immunoblotting, Lichen Planus, Male, Middle Aged, Nerve Tissue Proteins, Non-Fibrillar Collagens, Ramipril, Skin, Skin Diseases, Vesiculobullous