Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P 

Original publication




Journal article


Nat Genet

Publication Date





840 - 860


Alleles, Blood Glucose, Epigenesis, Genetic, Gene Expression Profiling, Genome, Human, Genome-Wide Association Study, Glycated Hemoglobin A, Humans, Multifactorial Inheritance, Physical Chromosome Mapping, Quantitative Trait Loci, Quantitative Trait, Heritable, Whites