Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State.
Müller NF., Wagner C., Frazar CD., Roychoudhury P., Lee J., Moncla LH., Pelle B., Richardson M., Ryke E., Xie H., Shrestha L., Addetia A., Rachleff VM., Lieberman NAP., Huang M-L., Gautom R., Melly G., Hiatt B., Dykema P., Adler A., Brandstetter E., Han PD., Fay K., Ilcisin M., Lacombe K., Sibley TR., Truong M., Wolf CR., Boeckh M., Englund JA., Famulare M., Lutz BR., Rieder MJ., Thompson M., Duchin JS., Starita LM., Chu HY., Shendure J., Jerome KR., Lindquist S., Greninger AL., Nickerson DA., Bedford T.
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gravely affected societies around the world. Outbreaks in different parts of the globe have been shaped by repeated introductions of new viral lineages and subsequent local transmission of those lineages. Here, we sequenced 3940 SARS-CoV-2 viral genomes from Washington State (USA) to characterize how the spread of SARS-CoV-2 in Washington State in early 2020 was shaped by differences in timing of mitigation strategies across counties and by repeated introductions of viral lineages into the state. In addition, we show that the increase in frequency of a potentially more transmissible viral variant (614G) over time can potentially be explained by regional mobility differences and multiple introductions of 614G but not the other variant (614D) into the state. At an individual level, we observed evidence of higher viral loads in patients infected with the 614G variant. However, using clinical records data, we did not find any evidence that the 614G variant affects clinical severity or patient outcomes. Overall, this suggests that with regard to D614G, the behavior of individuals has been more important in shaping the course of the pandemic in Washington State than this variant of the virus.