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Philadelphia-negative myeloproliferative neoplasms (MPNs) are an excellent tractable disease model of a number of aspects of human cancer biology, including genetic evolution, tissue-associated fibrosis, and cancer stem cells. In this review, we discuss recent insights into MPN biology gained from the application of a number of new single-cell technologies to study human disease, with a specific focus on single-cell genomics, single-cell transcriptomics, and digital pathology.

Original publication

DOI

10.1016/j.hoc.2021.01.002

Type

Journal article

Journal

Hematol Oncol Clin North Am

Publication Date

04/2021

Volume

35

Pages

279 - 293

Keywords

Digital pathology, Myeloproliferative neoplasm, Single-cell genomics