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Objectives Hypoparathyroidism is a rare disease in children that occurs as a result of autoimmune destruction of the parathyroid glands, a defect in parathyroid gland development or secondary to physical parathyroid gland disturbance. Typical symptoms of hypoparathyroidism present as hypocalcaemia and hyperphosphatemia due to decreased parathyroid hormone secretion and may lead to nerve and muscles disturbances resulting in clinical manifestation of tetany, arrhythmias and epilepsy. Currently, there is no conventional hormone replacement treatment for hypoparathyroidism and therapeutic approaches include normalising mineral levels using an oral calcium supplement and active forms of vitamin D. Case presentation We present the case of a 10-year-old girl with primary hypoparathyroidism who had no prior history of autoimmune disorders, but who subsequently developed systemic lupus erythematosus.

Original publication

DOI

10.1515/jpem-2020-0015

Type

Journal article

Journal

J Pediatr Endocrinol Metab

Publication Date

27/08/2020

Keywords

autoimmune polyglandular syndrome, hyperphosphatemia, hypocalcaemia, parathyroid hormone, primary hypoparathyroidism, systemic lupus erythematosus