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We have searched the human genome for genes that predispose to type 1 (insulin-dependent) diabetes mellitus using semi-automated fluorescence-based technology and linkage analysis. In addition to IDDM1 (in the major histocompatibility complex on chromosome 6p21) and IDDM2 (in the insulin gene region on chromosome 11p15), eighteen different chromosome regions showed some positive evidence of linkage to disease. Linkages to chromosomes 11q (IDDM4) and 6q (IDDM5) were confirmed by replication, and chromosome 18 may encode a fifth disease locus. There are probably no genes with large effects aside from IDDM1. Therefore polygenic inheritance is indicated, with a major locus at the major histocompatibility complex.

Original publication

DOI

10.1038/371130a0

Type

Journal article

Journal

Nature

Publication Date

08/09/1994

Volume

371

Pages

130 - 136

Keywords

Adolescent, Adult, Chromosome Mapping, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 6, Diabetes Mellitus, Type 1, Genetic Linkage, Genetic Markers, Genetic Predisposition to Disease, Genome, Human, Humans, Major Histocompatibility Complex