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The heart has a massive adenosine triphosphate (ATP) requirement, produced from the oxidation of metabolic substrates such as fat and glucose. Magnetic resonance spectroscopy offers a unique opportunity to probe this biochemistry: 31Phosphorus spectroscopy can demonstrate the production of ATP and quantify levels of the transport molecule phosphocreatine while 13Carbon spectroscopy can demonstrate the metabolic fates of glucose in real time. These techniques allow the metabolic deficits in heart failure to be interrogated and can be a potential future clinical tool.

Original publication

DOI

10.21037/cdt.2019.12.13

Type

Journal article

Journal

Cardiovasc Diagn Ther

Publication Date

06/2020

Volume

10

Pages

583 - 597

Keywords

Metabolism, cardiomyopathy, heart failure, magnetic resonance