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Thyroid function tests were performed on 16 clinically euthyroid patients with end-stage renal failure undergoing regular haemodialysis or continuous ambulatory peritoneal dialysis and compared with 8 healthy subjects. The patient groups were carefully matched, especially regarding relative duration of dialysis (mean of 24 months). Total serum thyroxine, total triiodothyronine, free thyroxine, free triiodothyronine and reverse triiodothyronine were significantly lower in both patient groups than control. The thyrothrophin response to the standard thyrotrophin-releasing hormone test was delayed and blunted. Using a novel concentration technique we measured loss of T4 in peritoneal dialysate effluent and found it to be approximately 10% of daily thyroidal T4 release.

Original publication

DOI

10.1159/000183823

Type

Journal article

Journal

Nephron

Publication Date

1986

Volume

43

Pages

164 - 168

Keywords

Adult, Aged, Humans, Kidney Failure, Chronic, Middle Aged, Peritoneal Dialysis, Continuous Ambulatory, Renal Dialysis, Thyroid Gland, Thyroid Hormones, Thyrotropin, Thyrotropin-Releasing Hormone, Thyroxine, Triiodothyronine