Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

BACKGROUND: Myocardial fibrosis is a key mechanism of left ventricular decompensation in aortic stenosis and can be quantified using cardiovascular magnetic resonance (CMR) measures such as extracellular volume fraction (ECV%). Outcomes following aortic valve intervention may be linked to the presence and extent of myocardial fibrosis. OBJECTIVES: This study sought to determine associations between ECV% and markers of left ventricular decompensation and post-intervention clinical outcomes. METHODS: Patients with severe aortic stenosis underwent CMR, including ECV% quantification using modified Look-Locker inversion recovery-based T1 mapping and late gadolinium enhancement before aortic valve intervention. A central core laboratory quantified CMR parameters. RESULTS: Four-hundred forty patients (age 70 ± 10 years, 59% male) from 10 international centers underwent CMR a median of 15 days (IQR: 4 to 58 days) before aortic valve intervention. ECV% did not vary by scanner manufacturer, magnetic field strength, or T1 mapping sequence (all p > 0.20). ECV% correlated with markers of left ventricular decompensation including left ventricular mass, left atrial volume, New York Heart Association functional class III/IV, late gadolinium enhancement, and lower left ventricular ejection fraction (p 

Original publication

DOI

10.1016/j.jacc.2019.11.032

Type

Journal article

Journal

J Am Coll Cardiol

Publication Date

28/01/2020

Volume

75

Pages

304 - 316

Keywords

T1 mapping, aortic stenosis, cardiovascular magnetic resonance, diffuse myocardial fibrosis, Aged, Aged, 80 and over, Aortic Valve Stenosis, Extracellular Fluid, Female, Follow-Up Studies, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Mortality, Myocardium, Prospective Studies, Stroke Volume, Ventricular Dysfunction, Left