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Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.

Original publication

DOI

10.1084/jem.20190689

Type

Journal article

Journal

J Exp Med

Publication Date

02/09/2019

Volume

216

Pages

1999 - 2009

Keywords

Adipose Tissue, White, Animals, Cell Proliferation, Eosinophils, Immunity, Innate, Interleukin-33, Interleukin-5, Lymphocytes, Mice, Inbred BALB C, Mice, Inbred C57BL, Stromal Cells