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F cells measure the presence of fetal hemoglobin, a heritable quantitative trait in adults that accounts for substantial phenotypic diversity of sickle cell disease and beta thalassemia. We applied a genome-wide association mapping strategy to individuals with contrasting extreme trait values and mapped a new F cell quantitative trait locus to BCL11A, which encodes a zinc-finger protein, on chromosome 2p15. The 2p15 BCL11A quantitative trait locus accounts for 15.1% of the trait variance.

Original publication

DOI

10.1038/ng2108

Type

Journal article

Journal

Nat Genet

Publication Date

10/2007

Volume

39

Pages

1197 - 1199

Keywords

Anemia, Sickle Cell, Carrier Proteins, Chromosome Mapping, Chromosomes, Human, Pair 2, Fetal Hemoglobin, Genetic Variation, Genome, Human, Humans, Nuclear Proteins, Phenotype, Quantitative Trait Loci, Zinc Fingers, beta-Thalassemia